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<b>Objectives</b> The purpose of this paper is to explore the mechanism of general arrangement (GA) design of large cruise ships as a contribution towards China's independent research and development of cruise ships.<b>Methods</b> Given the characteristics and expansibility of GA design, this paper expounds on two design mechanisms from the perspective of multi-disciplinary integration. These are the analysis of the design mechanism of themed functional areas of cruise ships based on the principle of axiomatic design, and the knowledge engineering-oriented modular design . Taking cruise ships that are currently typical worldwide as examples, the degree of mechanism fitting is also analyzed.<b>Results</b> The mapping law of themed functional area design from existing themed cruises to potential themed cruises can be obtained by establishing the relationship model between tourist's requirements and functional requirements; The cabin module of cruise decks can be effectively divided and the layout rules of cabin modules can be obtained by using a knowledge engineering-oriented modular design mechanism of cruise ships.<b>Conclusions</b> This paper integrates the principle of axiomatic design and knowledge engineering-oriented modular design to explore the GA design laws of large cruise ships, which has an important guiding significance for the GA design of the cruise ships in China.