tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis
oleh: Aaron M. Savage, Sathishkumar Kurusamy, Yan Chen, Zhen Jiang, Karishma Chhabria, Ryan B. MacDonald, Hyejeong R. Kim, Heather L. Wilson, Fredericus J. M. van Eeden, Angel L. Armesilla, Timothy J. A. Chico, Robert N. Wilkinson
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-02-01 |
Deskripsi
Calcium signalling downstream of VEGF is essential for VEGF-induced angiogenesis. Here Savage et al. show that Transmembrane Protein 33 (TMEM33) is required for angiogenesis and the endothelial calcium response to VEGF, revealing a function for TMEM33 in multicellular organisms.