Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation
oleh: Janet Berrios, Alice M. Stamatakis, Pranish A. Kantak, Zoe A. McElligott, Matthew C. Judson, Megumi Aita, Marie Rougie, Garret D. Stuber, Benjamin D. Philpot
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-02-01 |
Deskripsi
Mesoaccumbal terminals within the VTA are known to co-release both GABA and dopamine, although the functional role of the former has yet to be determined. Here, the authors find that non-canonical GABA release is regulated by the E3-ubiquitin ligase, UBE3A, and enhances optogenetic self-stimulation.