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Reactivity of bromoselenophenes in palladium-catalyzed direct arylations
oleh: Aymen Skhiri, Ridha Ben Salem, Jean-François Soulé, Henri Doucet
Format: | Article |
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Diterbitkan: | Beilstein-Institut 2017-12-01 |
Deskripsi
The reactivity of 2-bromo- and 2,5-dibromoselenophenes in Pd-catalyzed direct heteroarylation was investigated. From 2-bromoselenophene, only the most reactive heteroarenes could be employed to prepare 2-heteroarylated selenophenes; whereas, 2,5-dibromoselenophene generally gave 2,5-di(heteroarylated) selenophenes in high yields using both thiazole and thiophene derivatives. Moreover, sequential catalytic C2 heteroarylation, bromination, catalytic C5 arylation reactions allowed the synthesis of unsymmetrical 2,5-di(hetero)arylated selenophene derivatives in three steps from selenophene.