Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter
oleh: Hafsteinn Rannversson, Jacob Andersen, Lena Sørensen, Benny Bang-Andersen, Minyoung Park, Thomas Huber, Thomas P. Sakmar, Kristian Strømgaard
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-04-01 |
Deskripsi
Molecular details of how antidepressant drugs bind to the human serotonin transporter are not currently clear. Here, the authors introduce photo-cross-linkers into the protein and map the binding site of several antidepressants.