Bioinformatics Analysis of the Human Surfaceome Reveals New Targets for a Variety of Tumor Types
oleh: André L. Fonseca, Vandeclécio L. da Silva, Marbella M. da Fonsêca, Isabella T. J. Meira, Thayná E. da Silva, José E. Kroll, André M. Ribeiro-dos-Santos, Cléber R. Freitas, Raimundo Furtado, Jorge E. de Souza, Beatriz Stransky, Sandro J. de Souza
| Format: | Article |
|---|---|
| Diterbitkan: | Wiley 2016-01-01 |
Deskripsi
It is estimated that 10 to 20% of all genes in the human genome encode cell surface proteins and due to their subcellular localization these proteins represent excellent targets for cancer diagnosis and therapeutics. Therefore, a precise characterization of the surfaceome set in different types of tumor is needed. Using TCGA data from 15 different tumor types and a new method to identify cancer genes, the S-score, we identified several potential therapeutic targets within the surfaceome set. This allowed us to expand a previous analysis from us and provided a clear characterization of the human surfaceome in the tumor landscape. Moreover, we present evidence that a three-gene set—WNT5A, CNGA2, and IGSF9B—can be used as a signature associated with shorter survival in breast cancer patients. The data made available here will help the community to develop more efficient diagnostic and therapeutic tools for a variety of tumor types.