Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape
oleh: Paul Adrian Ginno, Lukas Burger, Jan Seebacher, Vytautas Iesmantavicius, Dirk Schübeler
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-10-01 |
Deskripsi
Mitosis poses a challenge for transcriptional programs, as it is thought that several proteins lose binding on condensed chromosomes. Here, the authors analyze the chromatin-bound proteome through the cell cycle, revealing retention of most transcription factors and preservation of the regulatory landscape.