Impairments of spatial memory in an Alzheimer’s disease model via degeneration of hippocampal cholinergic synapses
oleh: Houze Zhu, Huanhuan Yan, Na Tang, Xinyan Li, Pei Pang, Hao Li, Wenting Chen, Yu Guo, Shu Shu, You Cai, Lei Pei, Dan Liu, Min-Hua Luo, Hengye Man, Qing Tian, Yangling Mu, Ling-Qiang Zhu, Youming Lu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-11-01 |
Deskripsi
Cholinergic neurons in the diagonal band of Broca degenerate early in Alzheimer’s disease. Here the authors show that in healthy mice, these cholinergic inputs innervate newborn neurons in the hippocampus, and that loss of this innervation in an Alzheimer’s disease model leads to impairments in spatial memory.