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The botryomycome also called pyogenic granuloma, is an inflammatory tumor of the skin and mucous membranes often caused by superinfection of minor traumatism. Its uniqueness lies in its granulomatous organization in which each granulation contains bacteria and the predominance of many newly formed blood vessels, with the lights on variables ratings and a turgid endothelium responsible for the ulcero-hemorragic appearance. This delicate condition poses a real problem of treatment which included an appropriate antibiotherapy, surgical removal or electrocoagulation which, until today is more difficult in countries with limited income. An octagenarian came to our hospital with a large mass on the left foot. This mass had the appearance of a malignant tumor. However, the anatomopathologic diagnosis was showed that it was a pyogenic granuloma. The importance of the mass, its location on the sole of the foot, imposed the functional impairment of this member. Until today, the electrocoagulation is not disponible in our hospital and the surgical excision proposed to the patient was refused. So the patient was submited to an antibiotherapy made of Ceftriaxone and Gentalline at indicated doses until 15 days. After the failure of that antibiotherapy treatment, as last resort, the patient was submited for a month to another combination of antibiotics (free of cost) made of dapsone and rifampicin which give a very good result by treating the mass. This example could serve as a new weapon for the management of this disease in the South.