Secondary Metabolites from the Roots of Beilschmiedia tsangii and Their Anti-Inflammatory Activities

oleh: Ih-Sheng Chen, Chu-Hung Lin, Guei-Jane Wang, Hsun-Shuo Chang, Yun-Ting Huang

Format: Article
Diterbitkan: MDPI AG 2012-12-01

Deskripsi

Four new endiandric acid analogues, tsangibeilin C (1), tsangibeilin D (2), tricyclotsangibeilin (3) and endiandric acid M (4), one new lignan, beilschminol B (5) and two new sesquiterpenes, (+)-5-hydroxybarbatenal (6) and (4R,5R)-4,5-dihydroxycaryophyll-8(13)-ene (7), together with four known compounds (8–11), were isolated from the roots of Beilschmiedia tsangii (Lauraceae). The structures of 1–7 were determined by spectroscopic techniques. Among the isolates, endiandric acid M (4) exhibited moderate iNOS inhibitory activity, with an IC50 value of 31.70 µM.