Phase separation of Nur77 mediates celastrol-induced mitophagy by promoting the liquidity of p62/SQSTM1 condensates
oleh: Shuang-zhou Peng, Xiao-hui Chen, Si-jie Chen, Jie Zhang, Chuan-ying Wang, Wei-rong Liu, Duo Zhang, Ying Su, Xiao-kun Zhang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-10-01 |
Deskripsi
How phase separation participates in mitophagy remains unclear. Here the authors show that Nur77 and p62/SQSTM1 through “head-to-head” and “tail-to-tail” interactions form membraneless condensates capable of sequestering dysfunctional mitochondria and tethering them to autolysosome for degradation.