JMJD3 intrinsically disordered region links the 3D-genome structure to TGFβ-dependent transcription activation
oleh: Marta Vicioso-Mantis, Raquel Fueyo, Claudia Navarro, Sara Cruz-Molina, Wilfred F. J. van Ijcken, Elena Rebollo, Álvaro Rada-Iglesias, Marian A. Martínez-Balbás
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-06-01 |
Deskripsi
Here the authors demonstrate that TGFβ drives multi-enhancer contacts and ultimately gene activation during neuronal commitment, and that this requires the intrinsically disordered region (IDR) of the histone demethylase JMJD3 likely through its role in promoting phase-separated biomolecular condensates.