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We report an iridium(I)-catalyzed branched-selective C–H alkylation of <i>N</i>-arylisoindolinones with simple alkenes as the alkylating agents. The amide carbonyl group of the isoindolinone motif acts as the directing group to assist the ortho C–H activation of the <i>N</i>-aryl ring. With this atom-economic and highly branched-selective protocol, an array of biologically relevant <i>N</i>-arylisoindolinones were obtained in good yields. Asymmetric control was achieved with up to 87:13 er when a BiPhePhos-like chiral ligand was employed.