The multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity
oleh: Prateek Sharma, James R. J. Haycocks, Alistair D. Middlemiss, Rachel A. Kettles, Laura E. Sellars, Vito Ricci, Laura J. V. Piddock, David C. Grainger
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-11-01 |
Deskripsi
Transcription factors MarR and MarA confer multidrug resistance in enteric bacteria by modulating efflux pump and porin expression. Here, Sharma et al. show that MarA also upregulates genes required for lipid trafficking and DNA repair, thus reducing antibiotic entry and quinolone-induced DNA damage.