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Objective To investigate the changes of vaspin and TNF⁃α levels in gingival crevicular fluid (GCF) of type 2 diabetic (T2DM) patients with chronic periodontitis (CP) after non⁃surgical periodontal treatment. Methods 60 subjects were divided into 4 groups: DM ⁃CP group (patients with both T2DM and CP, n＝15); CP group (CP patients without T2DM, n＝15); DM group (T2DM patients without CP, n＝15), and CTRL group (systemically and periodontally healthy individuals, n＝15). The clinical parameters of periodontal tissue and GCF were measured before and 8 weeks after non⁃surgical periodontal treatment. The levels of vaspin and TNF⁃α were measured by ELISA. Results The lev⁃ els of vaspin and TNF⁃α in CP group were significantly higher than those in CTRL group (P < 0.05), while the levels of vaspin and TNF⁃α in CP group were significantly decreased after treatment (P < 0.05). There was a statistically signifi⁃ cant positive correlation between the total amount of vaspin and the total amount of TNF⁃α, the level of HbA1c, gingival index (GI) and probing depth (PD) (P < 0.05). Conclusion The results shows that vaspin and TNF⁃α are greatly de⁃creased in periodontitis after non⁃surgical periodontal treatment. It suggests that vaspin and TNF⁃ α in GCF may serve as inflammatory markers for the diagnosis and prognosis of diabetes and periodontitis.