Multiplexed single-molecule force spectroscopy using a centrifuge
oleh: Darren Yang, Andrew Ward, Ken Halvorsen, Wesley P. Wong
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-03-01 |
Deskripsi
Single molecule force spectroscopy (SMFS) has limitations in throughput and the ability to repeatedly interrogate single bonds. Here the authors repurpose a benchtop centrifuge and use DNA nanoswitches to enable high throughput SMFS capable of repeatedly measuring forces of single molecular pairs.