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The alterations of dopamine D2 receptor (D2R) and α1 adrenergic receptor (α1AR) expressions and developmental stages of seminiferous tubule were investigated in twenty-two male rats that underwent one of three Methamphetamine (METH) treatment regimes: acute binge (AB), escalating dose (ED) or escalating binge dose (ED-binge), in comparison with the control. The percentages of stage II seminiferous tubule were significantly decreased in ED and ED-binge groups. Reductions of D2R immunoreactivity in spermatocytes were found in all METH treated groups, while D2R reductions in elongated spermatids were found in ED and ED-binge groups. The expressions of α1AR in spermatocytes were increased in all METH treated groups as well as in round and elongated spermatids in ED and ED-binge groups. The results indicate that METH can cause changes in D2R and α1AR expressions in the testis of METH-addicted rats, which may disrupt DA and NE functions leading to changes of seminiferous epithelium development and consequently spermatogenesis impairment.