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Background and Aims: Microsurface patterns of the gastric mucosa can be observed using magnifying narrow-band imaging (M-NBI). However, the efficacy of M-NBI at low-magnification (LM-NBI) screening for detecting small gastric neoplasms is unclear. Methods: This prospective study was conducted at a single institution. LM-NBI, defined as minimal magnification that could reveal the microsurface pattern of the gastric mucosa, was performed after routine white-light imaging (WLI) observation of the stomach. Depending on the phase in which the neoplastic lesions were initially found, they were divided into the WLI group and the LM-NBI group, and the characteristics of these neoplastic lesions were investigated accordingly. Results: Sixty-five epithelial lesions (adenomas or noninvasive carcinomas) of 20 mm or less in diameter were identified in this study. Sixteen lesions were detected only with LM-NBI. Smaller lesions were detected using LM-NBI (P = .01). WLI took about 160 to 260 seconds, while LM-NBI required about 70 to 80 seconds. All lesions in the LM-NBI group had a background of map-like redness (n = 5) or atrophic/metaplastic mucosa (n = 11). Conclusions: LM-NBI was able to detect lesions overlooked by WLI, especially those in areas of map-like redness or atrophic/metaplastic mucosa of the stomach. Approximately one-quarter of newly diagnosed neoplasms were retrieved on routine examination during an extra 1.5 minutes.