RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair
oleh: Chloé Lescale, Vincent Abramowski, Marie Bedora-Faure, Valentine Murigneux, Gabriella Vera, David B. Roth, Patrick Revy, Jean-Pierre de Villartay, Ludovic Deriano
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-02-01 |
Deskripsi
Antigen receptor diversity relies on careful DNA cleavage and repair. Here the authors identify a functional interplay between RAG2 and XLF during V(D)J recombination, revealing an important role for the RAG complex in repairing induced DNA double-strand breaks and maintaining genome integrity.