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The paper describes a framework for promoting sustainability by using indicators for sustainable production. The concept of sustainable production is described as it is viewed by various organisms actions involved in the analysis of the sustainable industrial systems.The measure of sustainability is approached considering indicators of sustainable production, addressing both their dimensions and qualitative and quantitative features.The proposed framework refines the sustainability dimension for a case study which envisages sustainability in paper manufacturing. The analysis takes into account the life cycle analysis for the considered process since the environmental impact is seen as an essential sustainability indicator. Paper recycling and reuse is associated environmental and social costs, as a preferred alternative in waste minimization hierarchy in the manufacturing of non-trees eco-friendly paper.Proactive initiatives to improve the environmental performances of production process are considered as powerful tools for improving the paper manufacturing environmental footprint.