Lymphatic-preserving treatment sequencing with immune checkpoint inhibition unleashes cDC1-dependent antitumor immunity in HNSCC
oleh: Robert Saddawi-Konefka, Aoife O’Farrell, Farhoud Faraji, Lauren Clubb, Michael M. Allevato, Shawn M. Jensen, Bryan S. Yung, Zhiyong Wang, Victoria H. Wu, Nana-Ama Anang, Riyam Al Msari, Shiruyeh Schokrpur, Ida Franiak Pietryga, Alfredo A. Molinolo, Jill P. Mesirov, Aaron B. Simon, Bernard A. Fox, Jack D. Bui, Andrew Sharabi, Ezra E. W. Cohen, Joseph A. Califano, J. Silvio Gutkind
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-07-01 |
Deskripsi
Response rates to immune checkpoint inhibitors (ICI) in patients with head and neck squamous cell carcinoma (HNSCC) remain low. Here the authors show that ablative treatment of tumor-draining regional lymphatics, a standard of care approach in patients, impairs the tumor response to ICI in preclinical HNSCC models.