Biodegradable Mats for the Design of Bifunctional Biosensors for Glucose Detection in Urine
oleh: Nathalia O. Gomes, Rafaella T. Paschoalin, Stanley Bilatto, Amanda R. Sorigotti, Cristiane S. Farinas, Luiz H. C. Mattoso, Sergio A. S. Machado, Osvaldo N. Oliveira Jr., Paulo A. Raymundo-Pereira
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2023-05-01 |
Deskripsi
We introduce a bifunctional architecture to construct biosensors on solution-blow spinning fiber mats of polylactic acid (PLA) and polyethylene glycol (PEG). PLA/PEG mats acted as substrate for printing electrodes and as matrix to immobilize glucose oxidase (GOx). Prussian Blue nanoparticles (PB) decorated working electrodes to detect H<sub>2</sub>O<sub>2</sub> from enzymatic catalysis at a low applied potential (0 V vs. Ag/AgCl) with detection limit of 0.197 mM. The inexpensive bifunctional device (<US $0.25 per unit) exhibited a rapid response, long lifetime, and performance similar to the standard method for glucose monitoring in human urine samples. The PLA/PEG mats are sustainable alternative for biosensing and wearable applications.