Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

oleh: Behnam Nabet, Fleur M. Ferguson, Bo Kyung A. Seong, Miljan Kuljanin, Alan L. Leggett, Mikaela L. Mohardt, Amanda Robichaud, Amy S. Conway, Dennis L. Buckley, Joseph D. Mancias, James E. Bradner, Kimberly Stegmaier, Nathanael S. Gray

Format: Article
Diterbitkan: Nature Portfolio 2020-09-01

Deskripsi

The dTAG system is used to rapidly deplete tagged target proteins in vitro and in vivo, but there are context- and protein-specific differences in its effectiveness. Here, the authors develop a second generation dTAG molecule that can degrade previously recalcitrant target proteins in cells and mice.