Carijoside A, a Bioactive Sterol Glycoside from an Octocoral Carijoa sp. (Clavulariidae)
oleh: Chih-Yang Liu, Tsong-Long Hwang, Mei-Ru Lin, Yung-Husan Chen, Yu-Chia Chang, Lee-Shing Fang, Wei-Hsien Wang, Yang-Chang Wu, Ping-Jyun Sung
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2010-06-01 |
Deskripsi
A new bioactive sterol glycoside, 3β-O-(3',4'-di-O-acetyl-β-D-arabinopyranosyl)-25ξ-cholestane-3β,5α,6β,26-tetrol-26-acetate) (carijoside A, 1), was isolated from an octocoral identified as Carijoa sp. The structure of glycoside 1 was established by spectroscopic methods and by comparison with spectral data for the other known glycosides. Carijoside A (1) displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils and this compound exhibited moderate cytotoxicity toward DLD-1, P388D1, HL-60, and CCRF-CEM tumor cells.