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Quinazolin-4(3<i>H</i>)-ones: A Tangible Synthesis Protocol via an Oxidative Olefin Bond Cleavage Using Metal-Catalyst Free Conditions
oleh: Muhammad Sharif
Format: | Article |
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Diterbitkan: | MDPI AG 2020-04-01 |
Deskripsi
An efficient and selective oxidative procedure for the synthesis of quinazolinones from readily available <i>o</i>-aminobenzamides and styrenes was developed. A number of potentially pharmacologically relevant quinazolinones were prepared using metal- and catalyst-free conditions. The synthesis procedure highlights the sustainable operation, low-priced, free from perilous materials, green solvent and environmental affability. The synthesized products were isolated in moderate to excellent yields.