Find in Library

AIM: To discuss the role of humoral immunity and cellular immunity in the development of ocular myasthenia gravis in children by analyzing the clinical value of the indices including immunoglobulin, complement and T cell subgroup in peripheral blood. <p>METHODS: The concentrations of serum IgG, IgA, IgM, C3 and C4 in the myasthenia gravis group and the control group were detected by immune compare turbid. The contents of CD3⁺T cell, CD4⁺T cell and CD8⁺T cell were detected by flow cytometry. Data was analyzed by Independent-Sample Test.<p>RESULTS: There were no significant differences in contents of IgA, IgM, CD3⁺T cell, CD8⁺T cell between ocular myasthenia gravis group in children and the control group(<i>P</i>>0.05). The concentrations of serum IgG, C3 and C4 for myasthenia gravis group were lower than those of the control group(<i>P</i><0.05). The content of CD4⁺T cell were higher than those of the control group(<i>P</i><0.05).<p>CONCLUSION: Complement C3, C4 and CD4⁺T cell played an important role in immunology pathogenesis mechanism for ocular myasthenia gravis in children.