Increased amyloidogenic APP processing in APOE ɛ4-negative individuals with cerebral β-amyloidosis
oleh: Niklas Mattsson, Philip S. Insel, Sebastian Palmqvist, Erik Stomrud, Danielle van Westen, Lennart Minthon, Henrik Zetterberg, Kaj Blennow, Oskar Hansson
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-03-01 |
Deskripsi
Autosomal dominant Alzheimer's disease is thought to be caused by increased amyloidogenic APP processing. Mattson et al.show that association between brain Aβ and cerobrospinal fluid Aβ40 levels is stronger in APOE ɛ4 negative people, suggesting that increased processing may also underlie sporadic disease.