Derivation of iPSC lines from two patients with familial Alzheimer's disease from India

oleh: Ashaq H. Najar, K.M. Sneha, Aparna Ashok, Swathy Babu, Anand G. Subramaniam, Ramkrishnan Kannan, Biju Viswanath, Meera Purushottam, Mathew Varghese, Suhel Parvez, Mitradas M. Panicker, Odity Mukherjee, Sanjeev Jain

Format: Article
Diterbitkan: Elsevier 2019-01-01

Deskripsi

The current prevalence of diagnosable dementia in India is 1% of people over 60 years (~3.7 million people), but is estimated to increase significantly, as ~15% world's aged population (>65 years) would be resident here by 2020 (Shah et al., 2016). While several mutations that pose a familial risk have been identified, the ethnic background may influence disease susceptibility, clinical presentation and treatment response. In this study, we report a detailed characterization of two representative HiPSC lines from a well-characterized dementia cohort from India. Availability of these lines, and associated molecular and clinical information, would be useful in the detailed exploration of the genomic contribution(s) to AD.