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<i>Background and Objectives:</i> The aim of this study was to assess the consumption of dietary supplements (DS) among working-age residents of Lithuania from 2021 to 2023 with respect to social and demographic factors and an assessment of personal health. <i>Materials and Methods:</i> Using stratified sampling techniques, this study included three samples of working-age residents (1600 each year, 4800 total). Three surveys were conducted, the distribution of the respondents between groups was compared using the χ² test. <i>Results:</i> The consumption of DS significantly differed each year and accounted for 78.1%, 71.6%, and 72.7% of the respondents, respectively (<i>p</i> < 0.05). In 2022, the prevalence of the consumption of DS was lower in the majority of social and demographic groups (<i>p</i> < 0.05). In 2023, it was higher among females, younger residents, and those from larger families, who suffered from COVID-19 (<i>p</i> < 0.05). Despite similar changes found in the consumption of DS among those who negatively assessed their health, this group showed more prevalent consumption of DS among residents with non-university education, unemployed respondents, and those with lower income (<i>p</i> < 0.05). <i>Conclusions:</i> Despite a significantly lower prevalence in the consumption of DS in 2022, it was higher again in 2023. The assessment of personal health shows different habits in the consumption of DS.