Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis
oleh: Ping An, Lin-Lin Wei, Shuangshuang Zhao, Deanna Y. Sverdlov, Kahini A. Vaid, Makoto Miyamoto, Kaori Kuramitsu, Michelle Lai, Yury V. Popov
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-05-01 |
Deskripsi
Progressive fibrosis is a driver of morbidity and mortality in many chronic liver diseases, but the underlying mechanisms are incompletely understood. Here, the authors show that mitochondria-derived damage-associated molecular patterns are released from injured hepatocytes and can trigger fibrogenic activation of hepatic stellate cells.