Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins
oleh: Chen Zhao, Haripriya Sridharan, Ran Chen, Darren P. Baker, Shanshan Wang, Robert M. Krug
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-09-01 |
Deskripsi
The ubiquitin-like protein ISG15 can be covalently linked to cellular and viral proteins, but the consequences of this ‘ISGylation’ remain largely unknown. Here, Zhao et al.show that ISGylation of the influenza B virus nucleoprotein inhibits formation of a functional viral replication complex.