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Due to the tightened regulatory environment since the Fukushima accident, the capacity factor of Korean nuclear power plants has been declining since 2011. To overcome this circumstance, a shift from 18-month to 24-month cycle operation is being considered in Korea. Therefore, in this study, loading patterns(LPs) for 24-month cycle operation of the Korean standard nuclear power plant(OPR-1000) are suggested and economic evaluations are performed. A single-zone LP with 89 fresh fuels was evaluated to be optimal for 24-month operation of OPR-1000 in terms of economic gain. The 24-month operation of OPR-1000 with this LP gives a profit of 7.073 million dollars per year compared to 18-month operation.