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Solute carrier family 31 member 1 (<i>SLC31A1</i>) encodes a protein that functions as a homotrimer for the uptake of dietary copper. As a vital member of the cuproptosis gene family, it plays an essential role in both normal tissues and tumors. In this study, we analyzed <i>SLC31A1</i> across human cancer types to gain a better understanding of <i>SLC31A1</i>’s role in cancer development. We searched for information using online databases to analyze, systematically and comprehensively, the role of <i>SLC31A1</i> in tumors. Amongst nine cancer types, the expression of <i>SLC31A1</i> was significantly different between tumors and normal tissues. According to further analysis, pancreatic cancer had the highest mutation rate of the <i>SLC31A1</i> gene, and the methylation levels of the gene were significantly reduced in seven tumors. The expression of <i>SLC31A1</i> is also linked to the infiltration of tumors by immune cells, the expression of immune checkpoint genes, and immunotherapy markers (TMB and MSI), suggesting that <i>SLC31A1</i> may be of particular relevance in immunotherapy. This thorough analysis of <i>SLC31A1</i> across different types of cancer gives us a clear and comprehensive insight into its role in causing cancer on a systemic level.