Short-chain ketone production by engineered polyketide synthases in Streptomyces albus
oleh: Satoshi Yuzawa, Mona Mirsiaghi, Renee Jocic, Tatsuya Fujii, Fabrice Masson, Veronica T. Benites, Edward E. K. Baidoo, Eric Sundstrom, Deepti Tanjore, Todd R. Pray, Anthe George, Ryan W. Davis, John M. Gladden, Blake A. Simmons, Leonard Katz, Jay D. Keasling
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-11-01 |
Deskripsi
Mutating natural enzymes is effective in broadening the substrate or product range, but generally leads to reduced titers. Here the authors engineer hybrid polyketide synthases for efficient production of short-chain ketones from plant biomass hydrolysates in Streptomyces, which can increase the octane of gasoline.