A solvent-free synthesis of 1-(4-chlorophenyl)pyrazolidin-3-one in a ball mill
oleh: Xiong Zhang, Biao Wang, Binbin Zhang, Yifeng Wang
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2018-10-01 |
Deskripsi
An easy, solvent-free method for the synthesis of 1-(4-chlorophenyl)pyrazolidin-3-one has been achieved by grinding 4-chlorophenyl hydrazine and methyl acrylate in the presence of base in a ball mill. A systematic investigation of the reaction has been made in order to study the various factors affecting the reaction.