Transgenerational inheritance of impaired larval T cell development in zebrafish
oleh: Norimasa Iwanami, Divine-Fondzenyuy Lawir, Katarzyna Sikora, Connor O´Meara, Kohei Takeshita, Michael Schorpp, Thomas Boehm
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-09-01 |
Deskripsi
Evidence for transgenerational inheritance of epigenetic information in vertebrates is scarce. Here the authors report that homozygous dnmt1 mutant zebrafish are essentially normal, with the exception of impaired lymphopoiesis, with impaired larval (but not adult) T cell development being transmitted to subsequent generations by genotypically wildtype fish.