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Unravelling the origin of SARS-CoV-2: is the model good?
oleh: R. Frutos, L. Gavotte, C.A. Devaux
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2021-09-01 |
Deskripsi
MacLean and colleagues recently published a very elegant analysis demonstrating that SARS-CoV-2 carries signs of positive selection and that it was already adapted to humans prior to the emergence of COVID-19. Using the Spillover theory as a reference model for zoonotic emergence, they conclude that SARS-CoV-2 must have acquired this human adaptation in bats. We reinterpreted the data from MacLean et al. using a different model of zoonotic emergence as reference, the Circulation model. The use of the Circulation model provides a more parsimonious interpretation showing that this adaptation to humans occurs in the human population after primo infection.