Targeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignancies
oleh: Guy Biber, Aviad Ben-Shmuel, Elad Noy, Noah Joseph, Abhishek Puthenveetil, Neria Reiss, Omer Levy, Itay Lazar, Ariel Feiglin, Yanay Ofran, Meirav Kedmi, Abraham Avigdor, Sophia Fried, Mira Barda-Saad
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-09-01 |
Deskripsi
Cancer cells proliferate and invade via cytoskeletal proteins such as WASp, exclusively expressed in hematopoietic cells. Here the authors show a specific small molecule compound inhibiting cancer cell activity by WASp degradation and demonstrating its therapeutic potential in vitro and in vivo.