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Introduction: Giant phyllodes tumors are fibroepithelial lesions whose diameters exceed 10 cm. Core biopsy represents the best diagnostic method in order to distinct fibroadenomas from phyllodes tumors. Wide surgical resection with clear margins is the standard of treatment. Case Presentation: In this report, we describe the case of a 41-year-old woman, who presented with a rapid growth of a phyllodes tumor after an accidental bump on the breast and had to undergo mastectomy followed by breast reconstruction. Conclusion: There is possibly an etiological correlation between accident and phyllodes tumor growth.