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In eukaryotes, RNA molecules called long non-coding RNAs (LncRNAs) have been found. Molecules that exceed 200 base pairs in length are incapable of coding for proteins. Studying the function of LncRNAs in cancer has been the main focus of the current investigation, which has significantly impacted protein integrity and stability. LncRNAs can be regulated through various pathways, leading to chromatin changes and methylation or as miRNA sponges. The most common type of liver tumor worldwide is hepatocellular carcinoma (HCC), accounting for around 80 ​% of subjects. Nonetheless, the insufficiency of trustworthy molecular markers remains a significant challenge in HCC diagnosis and treatment evaluation. In HCC, LncRNAs such as MEG3, MALAT1, HULC, HOTAIR, and H19 dysregulation are closely associated with tumor expansion, metastasis, prognosis, and diagnosis. The primary goal of this investigation was to investigate the newly discovered roles and molecular mechanisms of LncRNAs in the pathophysiology of HCC cells to identify potential therapeutic targets.