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Dengue has a high prevalence in tropical countries including India. Although myalgias are a common musculoskeletal manifestation in dengue but myositis is unusual. The present case series describes three cases of female patients with dengue fever (35-year-old, 30-year-old and 37-year-old), who developed severe pain and tenderness in muscles and were diagnosed with myositis. The present case series emphasises the fact that, although the condition is usually self-limiting, but it has the potential to aggravate into life threatening conditions like acute respiratory and renal failure, if left unattended.