Stromal androgen signaling acts as tumor niches to drive prostatic basal epithelial progenitor-initiated oncogenesis
oleh: Alex Hiroto, Won Kyung Kim, Ariana Pineda, Yongfeng He, Dong-Hoon Lee, Vien Le, Adam W. Olson, Joseph Aldahl, Christian H. Nenninger, Alyssa J. Buckley, Guang-Qian Xiao, Joseph Geradts, Zijie Sun
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-11-01 |
Deskripsi
Prostate stromal cells can contribute to prostate tumorigenesis. Here the authors show that the loss of androgen receptor signalling in Gli1-lineage stromal cells diminishes prostate epithelial oncogenic transformation and tumor growth in mouse models and this is due to insulin-like growth factor binding protein 3-mediated inhibiting IGF1 and Wnt/β-catenin signalling activation.