The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42
oleh: Sui-Chih Tien, Hsiao-Hui Lee, Ya-Chi Yang, Miao-Hsia Lin, Yu-Ju Chen, Zee-Fen Chang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-01-01 |
Deskripsi
Cdc42 activity is important for apical-basal epithelial polarity. Here, the authors show that Shp2 disrupts Cdc42 activation, and by reducing the expression of histone deactylase 6, restores epithelial lumen formation in a cdc42-independent manner.