SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury
oleh: Meng-Li Wu, Feng-Liang Liu, Jing Sun, Xin Li, Xiao-Yan He, Hong-Yi Zheng, Yan-Heng Zhou, Qihong Yan, Ling Chen, Guo-Ying Yu, Junbiao Chang, Xia Jin, Jincun Zhao, Xin-Wen Chen, Yong-Tang Zheng, Jian-Hua Wang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Publishing Group 2021-12-01 |
Deskripsi
A schematic illustration of SARS-CoV-2 triggers MC rapid degranulation to induce alveolar epithelial inflammation and lung injury. SARS-CoV-2 triggers an immediate mast cell (MC) degranulation, which initiates the alveolar epithelial inflammation and disrupts the tight junction. MC stabilizers that block degranulation reduce virus-induced lung inflammation and injury.