m6A modification of a 3′ UTR site reduces RME1 mRNA levels to promote meiosis
oleh: G. Guy Bushkin, David Pincus, Jeffrey T. Morgan, Kris Richardson, Caroline Lewis, Sze Ham Chan, David P. Bartel, Gerald R. Fink
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-07-01 |
Deskripsi
Ime4p is a yeast N6-methyladenosine (m6A) methyltransferase with an unknown role in meiosis. Rme1p is a repressor of meiosis. Here the authors show that Ime4p methylates RME1 3′ UTR to reduce its expression and enable meiosis, thus providing an example of an m6A site with a physiological role.