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Context: Diarrhea is a preventable cause of under 5 years of mortality. Mothers are a primary caregiver for children at home during an illness so this study was planned. Aims: To estimate the demographic variables and level of knowledge of mothers (18-35 years of age) of under 5 children regarding ORS therapy. Settings and Design: The study was conducted in selected rural areas Chandandih (a small village in Raipur district). There is one sub-center and four Anganwadi's in Chandandih. The population of this study was the mother (18-35 yr.) of under 5yr children. In this study non-probability, purposive sampling was adopted for selecting the sample, and the sample size is 60 mothers. Methods and Material: In this study, 60 mothers were enrolled and their demographic variables were asked, then a self-structured questionnaire was administered. Statistical Analysis Used: The data were analyzed by using descriptive statistics. Demographic variables were analyzed by using descriptive measures (frequency and percentage) and knowledge was analyzed using descriptive statistics (means, standard deviation). Results: This study showed that little and average levels of knowledge regarding ORS therapy of mothers were around 63.34% which may be attributable to their qualification level which was maximum till primary education. Moreover, many were housewives. Only 16.66% had a good level of knowledge regarding ORS therapy. Conclusions: 63.34% had little or average knowledge regarding ORS therapy.