An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells
oleh: Ross D. Jones, Yili Qian, Velia Siciliano, Breanna DiAndreth, Jin Huh, Ron Weiss, Domitilla Del Vecchio
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-11-01 |
Deskripsi
Accurately predicting the behaviour of a genetic circuit remains difficult due to the lack of modularity. Here the authors quantify the effects of resource loading in mammalian systems and develop an endoribonuclease-based feedfoward controller to adapt gene expression to the effects of resource loading.