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Environmental drought stress threatens rice production. Previous studies have reported that related NAC (NAM, ATAF1/2, and CUC) transcription factors play an important role in drought stress. Herein, we identified and characterized OsNAC09<i>2</i>, encoding an NAC transcription factor that is highly expressed and induced during drought tolerance. <i>OsNAC092</i> knockout lines created using the clustered regularly interspaced palindromic repeats (CRISPR)-associated protein 9 (Cas9) system exhibited increased drought resistance in rice. RNA sequencing showed that the knockout of <i>OsNAC092</i> caused a global expression change, and differential gene expression is chiefly associated with “response to light stimulus,” “MAPK signaling pathway,” “plant hormone signal transduction,” “response to oxidative stress,” “photosynthesis,” and “water deprivation.” In addition, the antioxidants and enzyme activities of the redox response were significantly increased. <i>OsNAC092</i> mutant rice exhibited a higher ability to scavenge more ROS and maintained a high GSH/GSSG ratio and redox level under drought stress, which could protect cells from oxidant stress, revealing the importance of OsNAC092 in the rice’s response to abiotic stress. Functional analysis of OsNAC092 will be useful to explore many rice resistance genes in molecular breeding to aid in the development of modern agriculture.