Kindlin-2 links mechano-environment to proline synthesis and tumor growth
oleh: Ling Guo, Chunhong Cui, Kuo Zhang, Jiaxin Wang, Yilin Wang, Yixuan Lu, Ka Chen, Jifan Yuan, Guozhi Xiao, Bin Tang, Ying Sun, Chuanyue Wu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-02-01 |
Deskripsi
The mechano-properties of the Extracellular Matrix (ECM) are important for tumorigenesis. Here, the authors show that the stiffening of the ECM promotes translocation of the focal adhesion protein—Kindlin-2—to the mitochondria, where it interacts with the proline synthesis enzyme PYCR1, stimulating proline synthesis and cell proliferation.