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The article describes the technology transfer methods and scientific divulgation instruments through which COBRA project has achieved its main goal: the diffusion and transfer to SME s, operating in the field of Cultural Heritage into the Lazio Region, of ENEA technologies and skills available in the laboratories at the regional research centres, by developing also specific instruments. Most of these instruments have already been applied with success in interventions on different types of artworks, such as archaeological sites and frescos.